.  He studied at the University of Turin under Giuseppe Levi, along with fellow students Salvador Luria and Rita Levi-Montalcini, who also moved to the U.S. with him and won Nobel prizes. Perhaps more important than all this, the daily interaction through the years with a continuously changing group of young investigators shaped my work. Reaching the Pacific Ocean in Oregon was like arriving at a new world, an impression that continued and increased as we made our way south to Pasadena. This autobiography/biography was written He found that virus replication either led to a destruction of cells and the release of … It became obvious to me that some major effort had to be made to gain knowledge of the genes active in cells; the determination of the genes present in a given species would be the starting point. In 1962, he moved to the Salk Institute and then in 1972 to The Imperial Cancer Research Fund (now named the Cancer Research UK London Research Institute) where he was first appointed associate professor and then full professor. The results can be interpreted as implicating the mammary stem cells in the origin of the cancer. by the Laureate. Dulbecco was a part of the group which made key discoveries on the functioning of oncoviruses the viruses that can cause cancer when they infect animal cells. In 1938 I was discharged and returned to pathology. Renato Dulbecco (Catanzaro, 22 febbraio 1914 – La Jolla, 19 febbraio 2012) è stato un biologo e medico italiano. He encouraged me and offered me a small salary for working in his group. After visiting the major centers of animal virus work in the US I set out to discover the way to assay animal viruses by a plaque technique, similar to that used for phages, using cell cultures. Later in his career, he initiated the Human Genome Project and was jointly awarded the Nobel Prize in Physiology or Medicine in 1975 for furthering our understanding of cancer caused by viruses. ... Il DNA si può interrompere in punti precisi, facilmente identificabili, che creano i punti di riferimento sulla mappa. He was born to Leon-ardo and Maria Dulbecco in Catanzaro, Italy, on February 22, 1914, and he died in La Jolla, California, on February 19, 2012. He was drafted into the Italian army in World War II, but later joined the resistance. As demonstrated by Temin and Baltimore, who shared the Nobel Prize with Dulbecco, the transfer of viral genes to the cell is mediated by an enzyme called reverse transcriptase (or, more precisely, RNA-dependent DNA polymerase), which replicates the viral genome (in this case made of RNA) into DNA, which is later incorporated in the host genome. In the late 1950s, he took Howard Temin as a student, with whom, and together with David Baltimore, he would later share the 1975 Nobel Prize in Phy… Renato Dulbecco è l’uomo che ha lanciato nel 1985 il «Progetto genoma umano». There he started his studies about animal oncoviruses, especially of polyoma family. We also started investigating the changes in gene expression in human breast cancer, using two new approaches for improving the results: one was the isolation of pure cancer cells in order to avoid contamination with genes expressed by various types of normal cells present in a cancer; the other was to adopt the SAGE approach to measure gene expression, in order to avoid the complications of the microarray technology.  He was elected a Foreign Member of the Royal Society (ForMemRS) in 1974.. Oncoviruses are the cause of some forms of human cancers. During this time I gave up my lab, in order to concentrate on the needs of the Institute, which was going through a very difficult period. Dulbecco was born in Catanzaro (Southern Italy), but spent his childhood and grew up in Liguria, in the coastal city Imperia. È stato insignito del Premio Nobel per la medicina nel 1975.. Renato Dulbecco, nato a Catanzaro il 22 febbraio 1914, a soli sedici anni si iscrive alla facoltà di Medicina dell'Università di Torino, dove incontra due studenti, Salvador Luria e Rita Levi Montalcini ''che avranno poi una grande influenza sulla sua vita''. Dulbecco is the recipient of many other awards and honors. So I went to work with Giuseppe Levi, the professor of Anatomy, where I learned Histology and the rudiments of cell culture. My work throughout the years has been strongly influenced by my associates. Una vita per il DNA. He graduated from high school at 16, then moved to the University of Turin. At the end of the war my father, who was in the “Genio Civile”, was sent to Imperia, Liguria, where we stayed for many years. Look for popular awards and laureates in different fields, and discover the history of the Nobel Prize. I stayed in that city for a short time; my father was called into the army (World War I) and we moved to the north, Cuneo and Torino. In 1968, he and Joseph Sambrook showed that the viral DNA was integrated into the cellular DNA and proposed that the virus was adding genes to cells, implying that genes cause cancer. Dr. Dulbecco's early work on bacterial viruses led to the development of methods for investigating the process of viral infection of normal cells in culture. In 1988 I was asked to act as temporary president of the Salk Institute, and soon I was promoted to regular president, a position I held until 1992. Their work started my interest in the tumor virus fields. I concentrated on a model system, mammary cancers induced in rats, and I spent some time learning how to work with them. Dulbecco Dulbecco, Renato. When Mussolini’s government collapsed and Italy was taken over by the German army I hid in a small village in Piemonte and joined the Resistance, as physician of the local partisan units. What I remember most of that period, besides my family and the few friends, was the rocky beach where I spent most of my time during the summer holiday, and a small meteorological observatory, where I used to spend lots of my free time throughout the year. Views Duration 21. Per queste sue ricerche e per il loro successo, ha meritato il premio Nobel per la medicina o fisiologia nel 1975  As many Italian scientists Dulbecco did not have any PhD because it was not existent in the Italian higher education system (until when it was introduced in 1980). Renato Dulbecco, Nobel per la Medicina del 1975, ... Ma un altro importante lascito dello studioso è il grande sforzo fatto per sequenziare il DNA umano, che Dulbecco caldeggiò e per il quale si attivò, sollecitando tutta la comunità scientifica a fare altrettanto. In 1940 Italy entered World War II and Dulbecco was recalled and sent to the front in France and Russia, where he was wounded. Renato Dulbecco studied the effect of a simple DNA tumour virus on cultivated cells. Renato Dulbecco died on 19 February 2012.  In the late 1950s, he took Howard Temin as a student, with whom, and together with David Baltimore, he would later share the 1975 Nobel Prize in Physiology or Medicine for "their discoveries concerning the interaction between tumour viruses and the genetic material of the cell." One day I was told by Delbrück that a rich citizen had given Caltech a fund for work in the animal virus field. He died on February 19, 2012, three days before his 98th birthday. I used the technique for studying the biological properties of poliovirus. Temin and Baltimore arrived at the discovery of reverse transcriptase simultaneously and independently from each other; although Dulbecco did not take direct part in either of their experiments, he had taught the two methods they used to make the discovery.. One gene makes one protein. The information is sometimes updated with an addendum submitted I also went back to school, enrolling in regular courses in physics, which I pursued for the next two years. All through the student years I was at the top of my class although I was two years younger than everybody else. born Feb. 22, 1914, Catanzaro, Italy Italian born U.S. virologist. Thus I wrote a paper to the same effect in Science in 1986. There I had a narrow escape on the front of the Don during a major Russian offensive in 1942: I was hospitalized for several months and sent home. This profession had for me a strong emotional appeal, which was reinforced by having an uncle who was an excellent surgeon. Renato Dulbecco was an Italian-American virologist best known for winning the Nobel Prize for pioneering the growing of viruses in culture. From Les Prix Nobel en 1975, Editor Wilhelm Odelberg, [Nobel Foundation], Stockholm, 1976. During these years I collaborated with investigators of the National Research Council and of the National Cancer Institute in Milan. In the late fifties I had as a student Howard Temin, who, together with Harry Rubin, then a postdoctoral fellow in my laboratory, worked on the Rous Sarcoma Virus. Tasked with a mission to manage Alfred Nobel's fortune and has ultimate responsibility for fulfilling the intentions of Nobel's will. After the war he resumed his work at Levi's laboratory, but soon he moved, together with Levi-Montalcini, to the U.S., where, at Indiana University, he worked with Salvador Luria on bacteriophages. I remember that memorable trip from Indiana to California with my family in an old car, with our limited possessions in a small trailer behind. Renato Dulbecco was a pioneering molecular biologist, virologist, and cancer researcher. He had a remarkable career in science that spanned over 60 years. After hospitalization and the collapse of Fascism, he joined the resistance against the German occupation. Renato Dulbecco broke new ground in the study of viruses and cancer at Caltech and later was a founding member of the Salk Institute in La Jolla. It came to an end after five yeas, and was not renewed. After I received the Nobel Prize my research interest shifted to the study of naturally occurring cancers. MLA style: Renato Dulbecco – Biographical. I graduated from high school at 16 (1930) and went to the University in Torino. Molecular biologist who proved that virus-derived genes can trigger cancer. From the Molecular Biology of Oncogenic DNA Viruses to Cancer. To cite this section Dulbecco's discoveries allowed humans to better understand and fight cancer. This work has led to discovering many aspects of the interaction of this virus (and of SV40) with the host cells in lytic infection and transformation. My dream was to work in genetics of some very simple organism, possibly using radiations. I moved to Caltech in the summer 1949. For my degree, however, I went to morbid anatomy and pathology. I moved from Caltech to the Salk Institute in 1962, and in 1972 to the Imperial Cancer Research Fund Laboratories in London. This, according to the research leads to the acquisition of the tumor phenotype of the infected cells. In 1965 he received the Marjory Stephenson Prize from the Society for General Microbiology. In 1977 I returned to the Salk Institute, where I continued, with some collaborators, in the new direction, concentrating on the normal development of the gland. He asked me whether I was interested. Temin and Baltimore showed that, when a viral gene is transferred to a cell, an enzyme known as reverse transcriptase (RNA-dependent DNA polymerase), facilitates it and then replicates the … ... DNA and proteins are key molecules of the cell nucleus. Un lavoro terminato nel 2000 con la collaborazione di migliaia di scienziati. There he started his studies about animal oncoviruses, especially of polyoma family. In the end it helped the emergence of the genome project. In addition, it is well known that in the 1980s and 1990s, an understanding of reverse transcriptase and of the origins, nature, and properties of human immunodeficiency virus (HIV, of which there are two well-understood serotypes, HIV-1, and the less-common and less virulent HIV-2), the virus which, if unchecked, ultimately causes acquired immunodeficiency syndrome (AIDS), led to the development of the first group of drugs that could be considered successful against the virus, the reverse-transcriptase inhibitors, of which zidovudine is a well-known example. Nato in Calabria, a Catanzaro, a cinque anni si trasferisce in Liguria. Despite a strong interest in mathematics and physics, he decided to study medicine. In 1986 he was among the scientists who launched the Human Genome Project. I myself started working on an oncogenic virus, polyoma virus, in 1958, and continued until now. Dulbecco was the recipient of the Selman A. Waksman Award in Microbiology from the National Academy of Sciences in 1974. Renato Dulbecco. From early on at Salk, Renato recognized that the DNA of the virus was the active agent causing cell transformation. "The Nobel Prize in Physiology or Medicine 1975". These drugs are still used today as one part of the highly-active antiretroviral therapy drug cocktail that is in contemporary use. He received his M.D. We identified several genes controlling the process, some in a positive, others in a negative way. We continued the study of mammary development, using a tissue culture system in which differentiation occurs in vitro. Catanzaro, la città che gli dà i natali il 22 febbraio del 1914 è una casualità. I was part of the “Committee for National Liberation” of the city of Torino, and became a councillor of that city in the first postwar city council. Si è spento in California, dove viveva da molto tempo, quando mancavano due giorni ai suoi 98 anni. I was born in Catanzaro, Italy, from a Calabrese mother and a Ligurian father. The Nobel Prize in Physiology or Medicine 1975, Renato Dulbecco - Nobel Lecture: From the Molecular Biology of Oncogenic DNA Viruses to Cancer. I moved back to Levi’s Institute and worked together with Levi-Montalcini, who encouraged me to go to the USA to work in modern biology. Loss of simian virus 40 DNA-RNA hybrids from nitrocellulose membranes; implications for the study of virus--host DNA interactions. Proc Natl Acad Sci U S A. Several outreach organisations and activities have been developed to inspire generations and disseminate knowledge about the Nobel Prize. Furthermore, the mechanisms of carcinogenesis mediated by oncoviruses closely resemble the process by which normal cells degenerate into cancer cells. Understanding cancer 81 03:27 24. "Renato Dulbecco (1914–2012) Molecular biologist who proved that virus-derived genes can trigger cancer", "Renato Dulbecco: Viruses, genes, and cancer", "Renato Dulbecco and the new animal virology: Medicine, methods, and molecules", "The Nobel Prize in Physiology or Medicine 1975", "The properties of a mammary gland cancer stem cell", "Distinct populations of tumor-initiating cells derived from a tumor generated by rat mammary cancer stem cells", "Selman A. Waksman Award in Microbiology", https://en.wikipedia.org/w/index.php?title=Renato_Dulbecco&oldid=995576264, California Institute of Technology faculty, Italian military personnel of World War II, Members of the United States National Academy of Sciences, Nobel laureates in Physiology or Medicine, Recipients of the Albert Lasker Award for Basic Medical Research, Pages using infobox scientist with unknown parameters, Nobelprize template using Wikidata property P8024, Wikipedia articles with BIBSYS identifiers, Wikipedia articles with CINII identifiers, Wikipedia articles with SNAC-ID identifiers, Wikipedia articles with SUDOC identifiers, Wikipedia articles with Trove identifiers, Wikipedia articles with WORLDCATID identifiers, Creative Commons Attribution-ShareAlike License, This page was last edited on 21 December 2020, at 20:21. Addio a Renato Dulbecco, Se ne va il gentiluomo della ricerca, Addio a Renato Dulbecco. Using monoclonal antibodies against our cells we could identify several different types of cells, and proposed a role for them in the development of the gland. For more than a century, these academic institutions have worked independently to select Nobel Laureates in each prize category. Renato Dulbecco (, ; February 22, 1914 – February 19, 2012) was an Italian–American virologist who won the 1975 Nobel Prize in Physiology or Medicine for his work on oncoviruses, which are viruses that … In 1973 he was awarded the Louisa Gross Horwitz Prize from Columbia University together with Theodore Puck and Harry Eagle. Renato Dulbecco Scientist. He is survived by David Baltimore, Howard Temin and Renato Dulbecco shared the 1975 Nobel Prize in Physiology or Medicine for the discoveries concerning the interaction between tumor viruses and the genetic material of the cell. 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Renato Dulbecco lived a long life and was active in research even when he was well into his nineties.  From 1993 to 1997 he moved back to Italy, where he was president of the Institute of Biomedical Technologies at C.N.R. He was celebrated not only for his scientific achievements but also for inspiring a generation of younger scientists who went on to become distinguished in their own fields. Renato Dulbecco (/dʌlˈbɛkoʊ/ dul-BEK-oh, Italian: [reˈnaːto dulˈbɛkko, -ˈbek-]; February 22, 1914 – February 19, 2012) was an Italian–American virologist who won the 1975 Nobel Prize in Physiology or Medicine for his work on oncoviruses, which are viruses that can cause cancer when they infect animal cells. I went to work with Luria in Bloomington, Indiana, where I shared with him a small laboratory under the roof, to be soon joined by Jim Watson. Renato Dulbecco, nato nel 1914, ha lavorato fino a tarda età giungendo ad alcune delle più grandi scoperte nella biologia dei virus, dei tumori e, più recentemente, dedicandosi all'impresa del Progetto genoma umano.. Tue. Although I liked especially physics and mathematics for which I had considerable talent, I decided to study medicine. Without her affectionate encouragement and sound advice I doubt whether I would have been able to accomplish what I have done. These suggestions remained without consequences. In Levi’s laboratory I met two students who later had a strong influence on my life: Salvador Luria and Rita Levi-Montalcini. I was sent briefly to the French front, and a year later to Russia. Renato Dulbecco Un "cartografo" a San Remo . Renato Dulbecco, Nobel timido del Dna. Experiments with polyoma DNA 53 07:05 22. NobelPrize.org. I was fascinated by the beauty and immensity of the USA and the kindness of its people. However, the life of routine politics was not for me and within months I left that position to return to the laboratory. Dulbecco's study gave a basis for a precise understanding of the molecular mechanisms by which they propagate, thus allowing humans to better fight them. Albert Lasker Award for Basic Medical Research, Foreign Member of the Royal Society (ForMemRS) in 1974, "Fellowship of the Royal Society 1660-2015", "Howard M. Temin. In 1948 he published, with Salvador Luria, his first real scientific paper in Genetics on bacteriophage genetics and in 2008 published his last paper in PNAS on breast cancer tumor-initiating cells. This attracted the interest of Max Delbrück, who offered me a job in his group at Caltech. At only 22, he graduated in morbid anatomy and pathology under the supervision of professor Giuseppe Levi. Prix Nobel/ Nobel Lectures/The Nobel Prizes. L'impegno era immane e imponeva una collaborazione globale. During this work I became aware of the major difficulty in trying to identify cell types and their roles in both development and carcinogenesis. At the beginning of 2006, when I will reach 92 years of age, I will give up the Italian connections, and will retire at La Jolla, to follow the work going on at the Salk Institute, and to play the piano. Dulbecco's groundbreaking work on viruses was recognized in 1975 with the awarding of the Nobel Prize in Physiology or Medicine (shared with David Baltimore and Howard Temin). The paper had enormous resonance, at first mostly negative, but very soon converted into positive. Renato Dulbecco Biographical I was born in Catanzaro, Italy, from a Calabrese mother and a Ligurian father. Si tratta di una permanenza breve, seguita dal rientro della famiglia nei pressi di Imperia e dallo spostamento di Renato a Torino, dove si laurea soli 22 anni in medicina sotto la supervisione di Giuseppe Levi, grande personalità della medicina dell’epoca e padre della scrittrice Nata… Renato Dulbecco, (born February 22, 1914, Catanzaro, Italy—died February 19, 2012, La Jolla, California, U.S.), Italian American virologist who shared the Nobel Prize for Physiology or Medicine in 1975 with Howard M. Temin and David Baltimore, both of whom had studied under him.. Dulbecco obtained an M.D. Renato Dulbecco (Catanzaro, 1914 – La Jolla, 2012), premio Nobel per la Medicina nel 1975, è tra i biologi che hanno progettato il mappatura e poi il sequenziamento del genoma umano. These successes brought me an appointment first to associate professor, then to full professor at Caltech. Dulbecco, Renato. Dulbecco was actively involved in research into identification and characterization of mammary gland cancer stem cells until December 2011. Renato Dulbecco tra virus e genoma ... dalla diffusione degli antibiotici alla scoperta della doppia elica del Dna, fino ai vaccini contro la poliomielite (Salk e Sabin). Nobel Media AB 2020. In Torino I was a very successful student, but I soon realized that I was interested in biology more than in applied medicine. One of the reasons for the latter move was the opportunity to work in the field of human cancer. Renato Dulbecco, renowned virologist and cancer researcher, passed away peacefully at his home in La Jolla, CA, February 19, 2012, 3 days before his 98th birthday. from the University of Turin in 1936 and immigrated to the U.S. in 1947. A gene is made of DNA.  Dulbecco's examinations into the origin of mammary gland cancer stem cells in solid tumors was a continuation of his early investigations of cancer being a disease of acquired mutations. Since 1962 my scientific life has had the support of my second wife, Maureen, who for some years helped in my experiments. During these years he met Salvador Luria and Rita Levi-Montalcini, whose friendship and encouragement would later bring him to the United States. This dream became a reality after Luria, who had been in the USA since the beginning of the war, and was working in this very field, came in the summer of 1946 to Torino. I was urged in this direction by Rita Levi-Montalcini, who was herself preparing to go to another laboratory in USA. Oncogenic viruses, able to elicit tumour formation in animals, have been on the scientific scene for many years. In the summer of 1949 he moved to Caltech, joining Max Delbrück's group (see Phage group). Renato Dulbecco (/dʌlˈbɛkoʊ/ dul-BEK-oh, Italian: [reˈnaːto dulˈbɛkko, -ˈbek-]; February 22, 1914 – February 19, 2012) was an Italian–American virologist who won the 1975 Nobel Prize in Physiology or Medicine for his work on oncoviruses, which are viruses that can cause cancer when they infect anima 1972 Aug; 69(8):2160-4. The life I remember begins at Imperia, where I went to school, including the Ginnasio-Liceo “De Amicis”. I continued to visit the Institute of Morbid Anatomy in Torino where I joined in underground political activities together with Giacomo Mottura, a senior colleague. In 1992 I was asked by the Italian National Research Council to organize an Italian Genome Project. Innovation at Cold Spring Harbor 383 02:13 23. 10 December 1934-9 February 1994", Biographical Memoirs of Fellows of the Royal Society, "Renato Dulbecco, 97, Dies; Won Prize for Cancer Study". 22 Dec 2020. I stayed in that city for a short time; my father was called into the army (World War I) and we moved to the north, Cuneo and Torino. Within less than a year, I worked out such a method, which opened up animal virology to quantitative work. I resolved at that time that I would not like to live anywhere else in the world – a resolution that I changed only some twenty-three years later.
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